Z01 CP010169-03130 (Z01) | |||
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Title | Diet, genetics, and invasive cervical cancer in the U.S. | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Ziegler, Regina | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $6,050 | Project Dates | 01/01/1983 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (10.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Cervical Cancer (100.0%) | ||
Research Type | |||
Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors Nutritional Science in Cancer Prevention |
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Abstract | |||
A case-control study of invasive cervical cancer with 245 cases (160 white, 55 black, 23 Hispanic) and 545 controls (367 white, 137 black, 39 Hispanic) was conducted in five areas of the United States to examine serum homocysteine levels. Increased risk of cervical cancer was associated with greater serum homocysteine levels. This association likely reflects problems in one-carbon metabolism, such as folate, B12, and/or B6 inadequacy, and genetic polymorphisms. Recent vitamin supplement use was inversely associated with serum homocysteine levels as were serum and red blood cell folate measures, but neither fully explained the homocysteine/cervical cancer relationship. Further elucidation of this relationship is urgent as targeted fortification and/or supplementation can reduce homocysteine levels and potentially reduce cervical cancer incidence. |